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| CEDRO ROSA |
Family: Meliaceae
Genus: Cedrela
Species: odorata
Common Name: Cedro Rosa, Acajou Femelle,
Cedre
Espagnol, Cedre, Cedro Hembra, Cedro,
Spanish Cedar, Cedro
Colorado
Part Used: Bark
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| DESCRIPTION |
Properties/Actions: |
Febrifuge, Anti-malarial, Astringent, Vermifuge,
Antirheumatic |
Phytochemicals: |
Angolensic-acid-methyl-ester, Cedrelanol, Mexicanolide,
Odoratol, Odoratone, Photogedunine |
Traditional Remedy: |
One-half cup bark decoction 2 times daily or 2-4 ml of a
4:1 bark tincture twice daily. 2 to 5 grams of powdered bark in tablets or
capsules twice daily can be substituted if desired.
See Traditional Herbal Remedies
Preparation Methods page if necessary for definitions. |
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| Referenced Quotes |
Tico
Ethnobotanical Dictionary
CEDRELLA ODORATA L. Spanish cedar (E); Cedro
(S); Cobana (CR) . The seeds of this honey tree are vermifugal. The aromatic
wood is used for cigar boxes, moth-proof chests, etc., and is exported to the
United States from Panama. The root bark is febrifugal. Bayano Cuna make dugouts
of cedar, and the bottoms of old piraguas serve as benches (!). |
| COUNTRY |
ETHNOBOTANY: WORLDWIDE
USES |
Dominican Republic |
Astringent, Rheumatism |
Elsewhere |
Febrifuge, Fever, Vermifuge |
Haiti |
Fever, Malaria, Rheumatism |
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Clinical References |
- MacKinnon S, 1997 Antimalarial activity of tropical Meliaceae extracts and
gedunin derivatives. J Nat Prod 60(4), 336-341 (1997)
- Nores MM, 1997 Immunomodulatory activities of Cedrela lilloi and Trichilia
elegans aqueous leaf extracts. J Ethnopharmacol 55(2), 99-106 (1997)
- Castro O, 1996 Chemical and biological evaluation of the effect of plant
extracts against Plasmodium berghei. Rev Biol Trop 44(2A), 361-367 (1996)
- Benencia F, 1995 Immunomodulatory activities of Cedrela tubiflora leaf
aqueous extracts. J Ethnopharmacol 49(3), 133-139 (1995)
- Poddar G, 1971 A note on the chemical investigation on the bark of Cedrela
toona Roxb. Bull Calcutta Sch Trop Med 19(4), 89 (1971) (no abstract
available)
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| Clinical Abstracts |
Antimalarial
activity of tropical Meliaceae extracts and gedunin derivatives.
MacKinnon S, Durst T, Arnason JT, Angerhofer C, Pezzuto J, Sanchez-Vindas
PE, Poveda
LJ, Gbeassor M
J Nat Prod 1997 Apr;60(4):336-341
Ottawa-Carleton Institutes of Chemistry and Biology, University of Ottawa,
Ontario, Canada. Extracts of 22 species of Meliaceae were examined for
antimalarial activity using in vitro tests with two clones of Plasmodium
falciparum, one sensitive to chloroquine (W2) and one chloroquine-resistant
(D6). Twelve extracts were found to have activity, including extracts of Cedrela
odorata wood and Azadirachta indica leaves, which contained the limonoid
gedunin. These extracts were more effective against the W2 clone than the D6
clone, suggesting there is no cross-resistance to chloroquine. Gedunin was
extracted in quantity, and nine derivatives prepared for a structure-activity
study, which revealed essential functionalities for activity. The study also
included four other limonoids derived from related Meliaceae. Only gedunin had
better activity than chloroquine against the W2 clone. This active principle
could be used to standardize a popular crude drug based on traditional use of A.
indica in West Africa.
Immunomodulatory activities of Cedrela lilloi and Trichilia
elegans aqueous leaf extracts.
Nores MM, Courreges MC, Benencia F,
Coulombie FC
Laboratory of Virology, Faculty of Science, University of Buenos
Aires, Argentina.
J Ethnopharmacol 1997 Jan;55(2):99-106
The effects of
Cedrela lilloi and Trichilia elegans (Meliaceae) aqueous leaf extracts on
several parameters of the mouse immune system were studied. Both extracts showed
a strong anticomplementary activity and inhibited the phagocytosis of opsonized
sheep erythrocytes and the activation of the oxidative metabolism by opsonized
zymosan on peritoneal macrophages. The in vitro proliferation of spleen
T-lymphocytes was also impaired. Furthermore, treatment of mice with the
extracts diminished the delayed-type hypersensitivity response to sheep
erythrocytes. These results suggest that both extracts exert a marked
immunomodulatory effect on the mouse immune system.
Chemical and biological evaluation of
the effect of plant extracts against Plasmodium berghei.
Castro O,
Barrios M, Chinchilla M, Guerrero O
Universidad Nacional, Departamento de
Quimica, Heredia, Costa Rica.
Rev Biol Trop 1996 Aug;44(2A):361-367
Extracts from thirteen species of plants were evaluated by "in vivo"
antimalarial test against plasmodium berghei effects. Significant activities
were observed in the ethyl acetate and aqueous extracts, elaborated of Cedrela
tonduzii leaves, Trichilia havanensis and Trichilia americana barks, Neurolaena
lobata and Gliricidia sepium leaves and Duranta repens fruits. Compounds
identified include flavanoids, coumarins, mellilotic acid and iridoids which
some kind of biodinamic activity has previously been reported. The flavone
quercetin 1 purified from C. tonduzii gave strong antimalarial activity,
however, its respective glicosides (quercetin 3-glucoside 2 y robinine 7) showed
little significant activity.
Immunomodulatory activities of Cedrela tubiflora leaf aqueous
extracts.
Benencia F, Courreges MC, Nores MM, Coulombie
FC
Laboratory of Virology, University of Buenos Aires, Argentina.
J
Ethnopharmacol 1995 Dec 15;49(3):133-139
Human peripheral blood monocytes and
polymorphonuclear leukocytes treated with leaf aqueous extracts of the Meliaceae
tree Cedrela tubiflora showed a diminution in both their phagocytic and
respiratory burst activities. Besides, the extract inhibited the proliferation
of Concanavalin A stimulated lymphocytes. A decrease in the hemolytic capacity
of the human complement was also observed. The significance of the inhibitory
effect observed over some components of the human immune system closely related
with the inflammatory process is discussed. |
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