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| GUACO |
Family: Asteraceae
Genus: Mikania
Species: cordifolia, cordata
Common Names: Guaco, Bejuco De Finca, Cepu, Liane Francois, Liane Francoise, Matafinca, Vedolin
Part Used: Leaves, Bark, Root |
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DESCRIPTION
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Properties/Actions: |
Antiasthmatic, Analgesic, Antirheumatic, Anti-inflammatory, Febrifuge, Vermifuge |
Phytochemicals: |
One-half cup root decoction 1-2 times daily or 1-3 ml of a 4:1 root tincture twice daily.
See Traditional Herbal Remedies Preparation Methods page if necessary for definitions. |
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| COUNTRY |
ETHNOBOTANY WORLDWIDE USES
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Brazil |
Cancer, Cholera, Fever, Flu |
Dominican Republic |
Cholera, Fever, Flu |
Elsewhere |
Bite(Snake), Cholera |
Haiti |
Fever, Malaria, Syphilis |
Mexico |
Asthma, Bite(Dog), Bite(Snake), Fever, Malaria, Menoxenia, Rheumatism, Scorpion, Sore, Spasm, Stomach, Tetnus, Vermifuge |
Venezuela
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Bite(Snake), Fever, Tumor |
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| Clinical References |
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Peluso G, 1995 Studies on the inhibitory effects of caffeoylquinic acids on monocyte migration and superoxide ion production. J Nat Prod 58(5), 639-646 (1995)
- Rojas de Arias A, 1995 Mutagenicity, insecticidal and trypanocidal activity of some Paraguayan Asteraceae. J Ethnopharmacol 45(1), 35-41 (1995)
- Mandal PK, 1992 Stimulation of hepatic protein synthesis in response to Mikania cordata root extract in carbon tetrachloride-induced hepatotoxicity in mice. Ital J Biochem 41(6), 345-351 (1992)
- Ruppelt BM, 1991 Pharmacological screening of plants recommended by folk medicine as anti-snake venom--I. Analgesic and anti-inflammatory activities. Mem Inst Oswaldo Cruz86, 203-205 (1991)
- MC, 1990 Inhibition of leukotriene and platelet activating factor synthesis in leukocytes by the sesquiterpene lactone scandenolide. Planta Med 56(3), 268-270 (1990)
- Davino SC, 1989 Antimicrobial activity of kaurenoic acid derivatives substituted on carbon-15. Braz J Med Biol Res 22(9), 1127-1129 (1989)
- Bhattacharya S, 1988 Neuropharmacological studies on Mikania cordata root extract. Planta Med 54(6), 483-487 (1988)
- de Souza CP, 1984 Chemoprophylaxis of schistosomiasis: molluscacidal activity of natural products--assays with adult snails and oviposition An Acad Bras Cienc 56(3), 333-338 (1984)
- Herz W, 1977 Micordilin, a complex elemanolide from Mikania cordifolia. J Org Chem 42(10), 1720-1725 (1977)
- Wagner H, 1967 Note concerning the synthesis of the mikanins, a flavonol from Mikania cordata (Burm. f.) B.L. Robinson Chem Ber 100(5), 1768-1769 (1967)
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Studies on the inhibitory effects of caffeoylquinic acids on monocyte migration and superoxide ion production.
Peluso G, De Feo V, De Simone F, Bresciano E, Vuotto ML
Istituto di Biochimica delle Proteine ed Enzimologia, Napoli, Italy.
J. Nat Prod 1995 May;58(5):639-646
Three caffeoylquinic acids, isolated from the Peruvian plants Tessaria integrifolia and Mikania cordifolia that are used medicinally as anti-inflammatory agents, were tested for their activities on monocyte migration and superoxide anion production. 3,5-Di-O-caffeoylquinic and 4,5-di-O-caffeoylquinic acids exhibited an appreciable anti-inflammatory activity in vitro, while the tricaffeoyl derivative was inactive. |
Mutagenicity, insecticidal and trypanocidal activity of some Paraguayan Asteraceae.
Rojas de Arias A, Ferro E, Inchausti A, Ascurra M, Acosta N, Rodriguez E, Fournet A
Instituto de Investigaciones en Ciencias de la Salud (I.I.C.S.), Rio de la Plata y La Gerenza, Paraguay.
J Ethnopharmacol 1995 Jan;45(1):35-41
The insecticidal, moulting inhibition and trypanocidal effects of crude extracts of 7 Paraguayan Asteraceae were evaluated on Triatoma infestans and bloodstream forms of Trypanosoma cruzi, respectively. Both mutagenicity and toxicity were evaluated by sister chromatid exchange (SCE) in human peripheral lymphocyte culture and by the lethality test of Artemia salina. The ethanolic extracts from Chromolaena christieana (stem and bark), Achyrocline satureoides (leaves and flowers) and Mikania cordifolia (root and stem), at a concentration of 250 micrograms/ml, showed the highest percentage of lysis on bloodstream forms of Trypanosoma cruzi. The extracts of Chromolaena christieana and Achyrocline satureoides also presented high mutagenic and toxic capacity when they were evaluated by the SCEs assay and Artemia salina test, respectively. Insecticidal activity was only observed in the hexane extract of flowers of Achyrocline satureoides (45% of mortality), when 0.05 microgram of crude concentration was applied on Triatoma infestans. The ethanolic extracts of stem from Mikania cordifolia and Vernonia brasiliana inhibited the moulting of Triatoma infestans when it was compared with their controls. Since no ethnobotanical information on these plants has been found related to similar use in Paraguay, our findings suggest, for the first time, the potential anti-trypanocidal and moulting inhibition of these Asteraceae. |
Anticarcinogenic biological response of Mikania cordata: reflections in hepatic biotransformation systems.
Bishayee A, Chatterjee M
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Cancer Lett 1994 Jun 30;81(2):193-200
The chemopreventive role of an Indian medicinal plant Mikania cordata (Compositae), which is consumed as vegetable and advocated in folk-medicine, has been evaluated through its effects on Phase 1 and 2 of the hepatic drug-detoxifying enzyme system in rats. Although oral administration of a methanolic extract of this plant root (50, 100 or 150 mg/kg for 4, 8 or 12 weeks) has been found to have very little or no effect on hepatic microsomal cytochrome P-450 and cytochrome b5 contents as well as NADPH cytochrome c reductase activity, it afforded a marked induction of uridine diphosphoglucuronyl transferase activities of liver microsomes. The extract also significantly increased the activities of microsomal uridine diphosphoglucose dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate): quinine reductase and cytosolic glutathione s-transferases with a concomittant elevation in the contents of reduced glutathione. All these effects were found to be dose-dependent and maintained during 12 weeks of the extract treatment. Results of the study clearly indicate that the intracellular contents of active intermediates of various xenobiotics including chemical carcinogens would be reduced by the specific enhancement of drug-detoxifying enzymes in the liver of rats treated with the plant extract. |
Protective effects of Mikania cordata root extract against physical and chemical factors-induced gastric erosions in experimental animals.
Bishayee A, Chatterjee M
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Planta Med 1994 Apr;60(2):110-113
The effect of the methanolic fraction of Mikania cordata (Burm., B. L. Robinson) root extract was investigated for its possible ulceroprotective activity in male Sprague-Dawley rats. Oral administration of this extract (50, 100, or 150 mg/kg) significantly prevented the occurrence of water immersion stress-induced gastric ulcers in a dose-responsive manner. The extract also dose-dependently inhibited gastric ulcers induced by ethanol, aspirin, and phenylbutazone. The ED50 values of the extract in the above four ulcer models were found to be 95.1, 109.7, 125.5, and 136.2 mg/kg, respectively. The volume, acidity, and peptic activity of the gastric juice in pylorous-ligated rats were not altered upon administration of the extract (100 or 150 mg/kg) but it significatly and dose-dependently promoted the gastric mucus secretion in normal as well as stress- and ethanol-induced ulcerated animals. Based on these results, we conclude that M. cordata root extract possesses antiulcer activity and that the observed activity may be due to the modulation of defensive factors through an improvement of gastric cytoprotection. |
Stimulation of hepatic protein synthesis in response to Mikania cordata root extract in carbon tetrachloride-induced hepatotoxicity in mice.
Mandal PK, Bishayee A, Chatterjee M
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Ital J Biochem 1992 Nov;41(6):345-351
The effect of Mikania Cordata root extract was evaluated on the rate of hepatic protein synthesis in vivo in CCl4-induced liver damage. Pretreatment with the root extract (100 mg/kg, once daily for successive 5 days) showed a marked enhancement in the levels of hepatic DNA, RNA and protein content that were adversely affected with CCl4 treatment in the experimental mice. Increase in the total protein mass, fractional rate of protein synthesis (% of protein synthesized/day), total rate of protein synthesis (fractional rate x protein mass), ribosomal capacity (RNA/protein), ribosomal efficiency (rate/ribosome) and high turnover rate of protein (protein/DNA) in response to the pretreatment of the root extract in hepatic tissue indicated the tissue repair leading to a functional improvement of the hepatocytes that were disorganised with CCl4 intoxication. |
Inhibition of leukotriene and platelet activating factor synthesis in leukocytes by the sesquiterpene lactone scandenolide.
Ysrael MC, Croft KD
Research Centre for Natural Sciences, University of Santo Tomas, Manila, Philippines.
Planta Med 1990 Jun;56(3):268-270 The sesquiterpene lactone scandenolide, isolated from the Philippines medicinal plant Mikania cordata, at a dose of 100 microM completely inhibited whole blood chemiluminescence in response to the activators PMA and zymosan. In isolated inflammatory rat leukocytes this compound inhibited both leukotriene B4 and 5-HETE production with IC50 of 15 microM and 30 microM, respectively. The formation of the cyclooxygenase product thromboxane B2 was not inhibited in the concentration range 10 to 200 microM of scandenolide. The formation of the potent inflammatory mediator platelet activating factor (PAF) was suppressed by microM concentrations of scandenolide with an IC50 of less than 20 microM. The presence of a compound in M. cordata which inhibits some of the inflammatory mediators such as leukotrienes and PAF may explain at least in part some of its medicinal properties.
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