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| VASSOURINHA |
Family: Scrophulariaceae
Genus: Scoparia
Species: dulcis
Common
Names: Vassourinha, Escobilla, Piqu pichana, Ñuñco Pichana,
Cancharagua, Mastuerzo, Amarga, Anisillo, Bitterbroom, Boroemia,
Broomweed, Brum Sirpi, Brum Tahplira, du -Jhanga, Escoba Lisa, Escobilla
del Peru, Hierba De Dolor
Part Used: Entire Plant,
Roots |
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| DESCRIPTION |
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Properties/Actions: |
Analgesic, Antibacterial, Antidiabetic,
Antifungal, Antiherpetic, Anti-inflammatory, Antiseptic,
Antispasmodic, Antiviral, Emmenagogue, Emollient, Expectorant,
Febrifuge, Hypotensive, Hypocholesterolemic, Pectoral,
Refrigerant |
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Phytochemicals: |
3'-4'-5-5'-7-8-hexahydroxy flavone, 6-methoxy
benzoxazolin-2-one, 6-methoxy benzoxazolinone, 7-O-methyl
scutellarein, 7-o-beta-d-glucuronide, Acacetin, Alpha amyrin,
Apigenin, Benzoxazolinone, Beta sitosterol, Betulinic Acid,
Cynaroside, D Mannitol, Dulcinol, Dulcioic Acid, Gentisic Acid,
Glut-5(6)-en-3-beta-ol, Glutinol, Hymenoxin, Ifflaionic Acid, Iso
Vitexin, Linarin, Luteolin, Para Coumaric Acid, Scopadiol,
Scopadulcic Acid A, Scopadulcic Acid B, Scopadulciol, Scopadulin,
Scoparic Acid B, Scoparic Acid A, Scoparic Acid C, Scoparinol,
Scutellarein, Scutellarein-7-o-beta-d-glucuronide, Scutellarin,
Scutellarin Methyl Ester, Vicenin 2,
Vitexin |
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| ETHNOBOTANY: WORLDWIDE
USES |
Africa |
Ache(Ear), Conjunctivitis, Cough, Diuretic |
Amazonia |
Abortifacient, Aches, Antiemetic, Antipyretic, Bronchitis,
Contraceptive, Cough, Diarrhea, Erysipelas, Eye, Fever, Hemorrhoids,
Kidney Disease, Pains, Sores(gonorrheal), Swelling, Wounds |
Brazil |
Analgesic, Antipyretic, Bite(insect), Bronchitis, Cough,
Cardio-pulmonary Disorders, Diabetes, Earache, Emollient,
Expectorant, Fever, Gastric Disorders, Hemorrhoids, Hypertension,
Insecticide, Menstrual Disorder, Pectoral, Respiratory Disorders,
Skin, Vermifuge, Wounds |
Central America |
Bruise, Diarrhea, Emmenagogue, Fever, Gonorrhea, Gravel, Grip,
Hepatosis, Insecticide, Kidney, Menstrual Disorders, Purgative,
Sore(Throat), Stomach Disease, Stomach Pain, Wound |
Dominican Republic |
Astringent, Diabetes, Sore(Throat) |
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Elsewhere |
Albuminuria, Anemia, Aphrodisiac, Bite(Snake), Bronchitis,
Childbirth, Cicatrizant, Cough, Diabetes, Diarrhea, Diuretic,
Dysentery, Emetic, Fever, Gravel, Hyperglycemia, Hypertension,
Ketonuria, Kidney, Leprosy, Menstrual Disorders, Purgative,
Refrigerant, Retinitis, Toothache, Venereal, Vermifuge |
Haiti |
Ache(Ear), Ache(Head), Amygdalosis, Antiseptic, Astringent,
Blennorrhagia, Cough, Diabetes, Diuretic, Dysmenorrhea, Emetic,
Gonorrhea, Inflammation Menstrual(excessive bleeding), Nerve, Pile,
Sore, Sore(Throat), Spasm, Toothache, Tumor |
India |
Antivenin, Blennorrhagia, Dysentery, Earache, Fever, Headache,
Stomach, Toothache |
Malaya |
Childbirth, Cough, Expectorant, Labor, Opium-substitute,
Stomachache, Syphilis |
Nicaragua |
Anemia, Bite(insect), Bite(snake), Childbirth, Depurative,
Diarrhea, Fever, Heart, Itch, Liver, Malaria, Menstrual Disorders,
Stomach Disorders, Tonic, Venereal Disease |
Nigeria |
Analgesic, Antidiabetic, Antipyretic, Expectorant,
Diuretic |
Peru |
Astringent, Colic, Febrifuge, Hallucinogen, Hemorrhoids,
Mucolytic, Respiratory Disorders, Wounds |
Surinam |
Bronchitis, Coughs, Diabetes, Febrifuge, Jaundice, Rash |
Trinidad |
Antidote, Depurative, Diabetes, Dysmenorrhea, Eczema, Evil-Eye,
Jaundice, Mange, Marasmus, Ophthalmia, Rash, Sore |
Venezuela |
Astringent, Blennorrhagia, Diarrhea, Menorrhagia,
Metroxenia |
West Indies |
Diarrhea, Diabetes, Dysmenorrhea |
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Vassourinha is a erect annual herb growing up to a
half-meter in height and is widely distributed in many tropical
countries in the world. It is found in abundance in South America and
the Amazon Rainforest. It produces serrated leaves and many small white
flowers. Vassourinha has held a place in herbal medicine in every
tropical country where it grows, dating back many years, and it's use by
indigenous Indian tribes is well documented. |
Indigenous tribes in Ecuador brew a tea of the entire plant to reduce
swellings, aches and pains.(1)The Tikunas make a decoction
for washing wounds and women drink the same decoction for three days
each month during menstruation as a contraceptive and/or an
abortifacient.(1) In the rainforests of Guyane, indigenous
tribes use a leaf decoction as an antiseptic wash for wounds, as an
antiemetic for infants, as a soothing bath for fevers, and in poultices
for migraine headaches.(2) Indigenous peoples in Brazil use
the leaf juice to wash infected wounds and place it in the eyes for eye
problems,(3) and an make an infusion of the entire plant for
an expectorant and emollient.(4)Indigenous tribes in
Nicaragua use a hot water infusion and/or decoction of Vassourinha
leaves or the whole plant for belly pain, menstrual disorders, as an aid
in childbirth, to clean the blood, insect bites, fevers, heart problems,
liver and stomach disorders, malaria, venereal disease, and for a
general tonic.(5, 6) |
Vassourinha is still employed in herbal medicine throughout the
tropics. In Peru, a decoction of the entire plant is recommended for
upper respiratory problems, menstrual disorders, and fever while the
leaf juice is still employed for externally for wounds and
hemorrhoids.(7, 8) In Brazilian herbal medicine, the plant is
considered emollient, febrifuge, hypoglycemic, emmenagogue, hypotensive,
pectoral and expectorant; used for upper respiratory disorders,
bronchitis, coughs, menstrual disorders, diabetes, and hypertension just
to name a few of its many uses.(9-12)
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Some of Vassourinha's many uses in herbal medicine have been
validated by research. In laboratory tests, it showed active properties
against gram + bacteria (but not gram negative) and strong antifungal
actions as well.(13, 14) Phytochemical screening of
Vassourinha has shown that it is a source of novel flavonoids and
terpene plant chemicals, some of which have not been seen in science
before.(15,16) Many of Vassourinha's tested biological
activities are attributed to these phytochemicals; the main ones being
Scopadulcic Acids A & B, Scopadiol, Scopadulciol, Scopadulin,
Scoparic Acids A, B, and C.(17 - 24) Vassourinha's
hypoglycemic actions in two diabetic patients were reported in
1985.(25) In animal studies between 1993 and 1996,
researchers showed that different extracts of Vassourinha demonstrated
anti-inflammatory activity in rats, antispasmodic activity in guinea
pigs and rats, analgesic actions in mice, and hypertensive properties in
rats and dogs.(26, 27) In these animal studies they reported
no toxicity in amounts up to 2 grams per kilogram of body weight. The
antitumorous activity of scopadulcic acid B, one of Vassourinha's main
active constituents, was demonstrated in a 1993 study.(28) This same phytochemical and another called Scopadulin demonstrated antiviral properties in two prior studies, including
against Herpes Simplex I in vivo in hamsters.(29, 30) An
ethanol extract of the whole plant of Vassourinha demonstrated an
ability to inhibit receptor binding to both dopamine and serotonin
receptors in another recent study.(31)
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Scientists have been trying since the mid 1990's to synthesize
several phytochemicals found in Vassourinha, including scopadulcic acid
B, for their use in the pharmaceutical industry. Since before scientists
became interested in Vassourinha, and probably long afterward,
herbalists and natural health practitioners will continue to use the
natural plant for a effective natural remedy for upper respiratory
problems and viruses, menstrual problems, and as a natural hypotensive,
analgesic and antispasmodic agent when needed.
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| Footnotes: |
- Schultes, R.E., and Raffauf, 1990. The Healing Forest.
Medicinal and Toxic Plants of the Northwest Amazonia, R.F.
Dioscorides Press: Portland Oregon.
- Grenand, P., Moretti, C., Jacquemin, H., 1987. Pharmacopees
taditionnels en Guyane: Créoles, Palikur, Wayãpi. Editorial
l-ORSTROM, Coll. Mem No. 108. Paris, France
- Branch, L.C. and da Silva, I.M.F. 1983. "Folk Medicine of Alter do
Chao, Para, Brazil." Acta Amazonica13(5/6):737-797.
- Hirschmann, G., et.al., 1990. A Survey of Medicinal Plants of
Minas Gerais, Brazil. J Ethnopharmacol29 2: 159-172 (1990)
- Coee, F., et.al., 1996. Ethnobotany of the Garifuna of Eastern
Nicaragua. Econ Bot 50 1: 71-107 (1996)
- Dennis, P. 1988. Herbal Medicine among the Miskito of Eastern
Nicaragua. Econ Bot 42 1: 16-28 (1988)
- Ramirez, V., et.al. 1988. Vegetales Empleados En Medicina
Tradicional Norperuana Banco Agrario Del Peru & Nacl Univ
Trujillo, Trujillo, Peru, June, 1988 : 54pp- (1988)
- Kember Mejia and Reng, Elsa 1995. Plantas medicinales de uso
popular en la Amazonia Peruana. AECI and IIAP: Lima, Peru.
- Cruz, G.L. 1995. Dicionario Das Plantas Uteis Do Brasil,
5th ed., Bertrand: Rio de Janeiro, Brazil
- Matos, FJ Abreu, 1994. Farmacias vivas, sistema de utilizaco
de plantas medicinais projetado para pequenas comunidades.
Edicoes UFC: Fortaleza, Brazil
- de Almeida, E.R., 1993. Plantas Medicinais Brasileiras,
Conhecimentos Populares E Cientificos. Hemus Editora Ltda.: Sau
Paulo, Brazil.
- Coimbra, Raul, 1994. Manual de Fitoterapia 2nd Ed.,
Editora Cejup: Belem, Brazil.
- Laurens, A., et.al., 1985 Antimicrobial Activity of Some Medicinal
Species of Dakar Markets. Pharmazie 40 7: 482-485 (1985)
- Singh, J., et.al., 1994 Antifungal Activity of Mentha spicata. Int J Pharmacog 32 4: 314-319 (1994)
- Ramesh, P., et.al. 1979. Flavonoids of Scoparia dulcis and
Stemodia viscosa Curr Sci 48 : 67- (1979)
- Mahato, S., et al., 1981. Triterpenoids of Scoparia dulcis. Phytochemistry 20 : 171-173 (1981)
- Hayashi, T., et.al. 1987 Scopadulcic Acid-a and -B, New
Diterpenoids with a Novel Skeleton, from a Paraguayan Crude Drug
"Typycha Kuratu" (Scoparia dulcis L.). Tetrahedron Lett 28
32: 3693-3696 (1987)
- Kawasaki, M., 1987 Structure of Scoparic Acid A, a New
Labdane-type Diterpenoid from a Paraguayan Crude Drug "Typycha Kurata"
(Scoparia dulcis L.).Chem Pharm Bull 35 9: 3963-3966 (1987)
- Hayashi, T., 1987 Structures of New Diterpenoids from Paraguayan
Crude Drug "Typycha Kuratu" (Scoparia Dulcis L.).Tennen Yuki
Kagobutsu Toronkai Koen Yoshishu 29 : 544-551 (1987)
- Hayashi, T., 1990 Antiviral Agents of Plant Origin. Iii.
Scopadulin, a Novel Tetracyclic Diterpene from Scoparia dulcis L. Chem Pharm Bull 38 4: 945-947 (1990)
- Ahmed, M., 1990 Diterpenoids from Scoparia dulcis. Phytochemistry 29 9: 3035-3037 (1990)
- Hayashi, T., 1991 Scopadulciol, an Inhibitor of Gastric H+,
K+-atpase from Scoparia dulcis, and its Structure-activity
Relationships. J Nat Prod 54 3: 802-809 (1991)
- Hayashi, T., 1992 Scoparic Acid A, a Beta-glucuronidase Inhibitor
from Scoparia dulcis. J Nat Prod55 12: 1748-1755 (1992)
- Hayashi, T., 1993. A New Chemotype of Scoparia dulcis. Phytochemistry 32 2: 349-352 (1993)
- Jain, H. C., 1985 Indian Plants with Oral Hypoglycaemic Activity. Abstr Internat Res Cong Nat Prod Coll Pharm, Univ N Carolina
Chapel Hill NC July 7-12 1985 : Abstr-152 (1985)
- Freire, S., et.al., 1996. Sympathomimetic Effects of Scoparia
dulcis L. and Catecholamines Isolated from Plant Extracts. J Pharm
Pharmacol 48 6: 624-628 (1996)
- Freire, S., et.al., 1993. Analgesic and Antiinflammatory
Properties of Scoparia dulcis L. Extracts and Glutinol in Rodents. Phytother Res 7 6: 408-414 (1993)
- Nishino H, 1993. Antitumor-promoting activity of scopadulcic acid
B, isolated from the medicinal plant Scoparia dulcis L. Oncology
50(2), 100-103 (1993)
- Hayashi T, 1990. Antiviral agents of plant origin. III.
Scopadulin, a novel tetracyclic diterpene from Scoparia dulcis L. Chem Pharm Bull (Tokyo) 38(4), 945-947 (1990)
- Hayashi K, 1988. In vitro and in vivo antiviral activity of
scopadulcic acid B from Scoparia dulcis, Scrophulariaceae, against
herpes simplex virus type 1. Antiviral Res 9(6), 345-354
(1988)
- Hasrat, J., et.,al., 1997 Medicinal Plants in Surianame: Screening
of Plant Extracts for Receptor Binding Activity. Phytomedicine 4 1: 59-65 (1997)
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REFERENCED QUOTES ON YERBA MATE
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10 "Scoparia dulcis L.
Scrophulariaceae. "Bati matsoti", "Escobilla", "Ñucñu-pichana", "Piqui
pichana". Leaf infusion used for bronchitis, cough, diarrhea, fevers,
kidney diseases, and hemorrhoids (RVM, VDF). Leaf infusion antidiarrheic
and emetic (CAA). Antiseptic leaf decoction used for wounds; and fever.
"Créoles" use the leaf decoction mixed with maternal milk as an
antiemetic for infants. Dried leaves used by as a marihuana substitute.
"Palikur" use the leaf decoction in antipyretic baths and in poultices
for migraine headaches (GMJ). Ecuadorians take the tea for pain and
swelling (SAR). "Tikuna" drink the tea, with or without "paico", three
days during the menses as an abortifacient or contraceptive (SAR). Four
to five plants tied together make the typical river-dweller's broom
(RVM). Brazilians add the root to the bath when "cleaning their blood"
(BDS). They apply strained leaf juice for eye ailments; and to infected
wounds (erysipelas) (BDS)." |
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- Freire SM, 1996. Sympathomimetic effects of Scoparia dulcis L. and
catecholamines isolated from plant extracts. J Pharm Pharmacol 48(6),
624-628 (1996)
- Nishino H, 1993. Antitumor-promoting activity of scopadulcic acid
B, isolated from the medicinal plant Scoparia dulcis L. Oncology
50(2), 100-103 (1993)
- Hayashi T, 1992. Scoparic acid A, a beta-glucuronidase inhibitor
from Scoparia dulcis. J Nat Prod 55(12), 1748-1755 (1992)
- Hayashi T, 1991. Scopadulciol, an inhibitor of gastric H+,
K(+)-ATPase from Scoparia dulcis, and its structure-activity
relationships. J Nat Prod 54(3), 802-809 (1991)
- Freire SM, 1991. Analgesic activity of a triterpene isolated from
Scoparia dulcis L. (Vassourinha). Mem Inst Oswaldo Cruz 86, 149-151
(1991)
- Asano S, 1990. Reversible inhibitions of gastric H+,K(+)-ATPase by
scopadulcic acid B and diacetyl scopadol. New biochemical tools of
H+,K(+)-ATPase. J Biol Chem 265(36), 22167-22173 (1990)
- Hayashi T, 1990. Scopadulcic acid B, a new tetracyclic diterpenoid
from Scoparia dulcis L. Its structure, H+, K(+)-adenosine
triphosphatase inhibitory activity and pharmacokinetic
behaviour in
rats. Chem Pharm Bull (Tokyo) 38(10), 2740-2745 (1990)
- Hayashi T, 1990. Antiviral agents of plant origin. III.
Scopadulin, a novel tetracyclic diterpene from Scoparia dulcis L. Chem
Pharm Bull (Tokyo) 38(4), 945-947 (1990)
- Hayashi T, 1988. A cytotoxic flavone from Scoparia dulcis L. Chem
Pharm Bull (Tokyo) 36(12), 4849-4851 (1988)
- Hayashi K, 1988. In vitro and in vivo antiviral activity of
scopadulcic acid B from Scoparia dulcis, Scrophulariaceae, against
herpes simplex virus type 1. Antiviral Res 9(6), 345-354 (1988)
- Kawasaki M, 1987. Structure of scoparic acid A, a new labdane-type
diterpenoid from a Paraguayan crude drug "Typycha Kuratu" (Scoparia
dulcis L.) Chem Pharm Bull (Tokyo) 35(9), 3963-3966
(1987
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