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VASSOURINHA
Family: Scrophulariaceae
Genus: Scoparia
Species: dulcis
Common Names:
Vassourinha, Escobilla, Piqu pichana, Ñuñco Pichana, Cancharagua, Mastuerzo, Amarga, Anisillo, Bitterbroom, Boroemia, Broomweed, Brum Sirpi, Brum Tahplira, du -Jhanga, Escoba Lisa, Escobilla del Peru, Hierba De Dolor
Part Used: Entire Plant, Roots
DESCRIPTION
Properties/Actions:
Analgesic, Antibacterial, Antidiabetic, Antifungal, Antiherpetic, Anti-inflammatory, Antiseptic, Antispasmodic, Antiviral, Emmenagogue, Emollient, Expectorant, Febrifuge, Hypotensive, Hypocholesterolemic, Pectoral, Refrigerant
Phytochemicals:
3'-4'-5-5'-7-8-hexahydroxy flavone, 6-methoxy benzoxazolin-2-one, 6-methoxy benzoxazolinone, 7-O-methyl scutellarein, 7-o-beta-d-glucuronide, Acacetin, Alpha amyrin, Apigenin, Benzoxazolinone, Beta sitosterol, Betulinic Acid, Cynaroside, D Mannitol, Dulcinol, Dulcioic Acid, Gentisic Acid, Glut-5(6)-en-3-beta-ol, Glutinol, Hymenoxin, Ifflaionic Acid, Iso Vitexin, Linarin, Luteolin, Para Coumaric Acid, Scopadiol, Scopadulcic Acid A, Scopadulcic Acid B, Scopadulciol, Scopadulin, Scoparic Acid B, Scoparic Acid A, Scoparic Acid C, Scoparinol, Scutellarein, Scutellarein-7-o-beta-d-glucuronide, Scutellarin, Scutellarin Methyl Ester, Vicenin 2, Vitexin
ETHNOBOTANY: WORLDWIDE USES
Africa
Ache(Ear), Conjunctivitis, Cough, Diuretic
Amazonia
Abortifacient, Aches, Antiemetic, Antipyretic, Bronchitis, Contraceptive, Cough, Diarrhea, Erysipelas, Eye, Fever, Hemorrhoids, Kidney Disease, Pains, Sores(gonorrheal), Swelling, Wounds
Brazil
Analgesic, Antipyretic, Bite(insect), Bronchitis, Cough, Cardio-pulmonary Disorders, Diabetes, Earache, Emollient, Expectorant, Fever, Gastric Disorders, Hemorrhoids, Hypertension, Insecticide, Menstrual Disorder, Pectoral, Respiratory Disorders, Skin, Vermifuge, Wounds
Central America
Bruise, Diarrhea, Emmenagogue, Fever, Gonorrhea, Gravel, Grip, Hepatosis, Insecticide, Kidney, Menstrual Disorders, Purgative, Sore(Throat), Stomach Disease, Stomach Pain, Wound
Dominican Republic
Astringent, Diabetes, Sore(Throat)
Elsewhere
Albuminuria, Anemia, Aphrodisiac, Bite(Snake), Bronchitis, Childbirth, Cicatrizant, Cough, Diabetes, Diarrhea, Diuretic, Dysentery, Emetic, Fever, Gravel, Hyperglycemia, Hypertension, Ketonuria, Kidney, Leprosy, Menstrual Disorders, Purgative, Refrigerant, Retinitis, Toothache, Venereal, Vermifuge
Haiti
Ache(Ear), Ache(Head), Amygdalosis, Antiseptic, Astringent, Blennorrhagia, Cough, Diabetes, Diuretic, Dysmenorrhea, Emetic, Gonorrhea, Inflammation Menstrual(excessive bleeding), Nerve, Pile, Sore, Sore(Throat), Spasm, Toothache, Tumor
India
Antivenin, Blennorrhagia, Dysentery, Earache, Fever, Headache, Stomach, Toothache
Malaya
Childbirth, Cough, Expectorant, Labor, Opium-substitute, Stomachache, Syphilis
Nicaragua
Anemia, Bite(insect), Bite(snake), Childbirth, Depurative, Diarrhea, Fever, Heart, Itch, Liver, Malaria, Menstrual Disorders, Stomach Disorders, Tonic, Venereal Disease
Nigeria
Analgesic, Antidiabetic, Antipyretic, Expectorant, Diuretic
Peru
Astringent, Colic, Febrifuge, Hallucinogen, Hemorrhoids, Mucolytic, Respiratory Disorders, Wounds
Surinam
Bronchitis, Coughs, Diabetes, Febrifuge, Jaundice, Rash
Trinidad
Antidote, Depurative, Diabetes, Dysmenorrhea, Eczema, Evil-Eye, Jaundice, Mange, Marasmus, Ophthalmia, Rash, Sore
Venezuela
Astringent, Blennorrhagia, Diarrhea, Menorrhagia, Metroxenia
West Indies
Diarrhea, Diabetes, Dysmenorrhea
Vassourinha is a erect annual herb growing up to a half-meter in height and is widely distributed in many tropical countries in the world. It is found in abundance in South America and the Amazon Rainforest. It produces serrated leaves and many small white flowers. Vassourinha has held a place in herbal medicine in every tropical country where it grows, dating back many years, and it's use by indigenous Indian tribes is well documented.
Indigenous tribes in Ecuador brew a tea of the entire plant to reduce swellings, aches and pains.(1)The Tikunas make a decoction for washing wounds and women drink the same decoction for three days each month during menstruation as a contraceptive and/or an abortifacient.(1) In the rainforests of Guyane, indigenous tribes use a leaf decoction as an antiseptic wash for wounds, as an antiemetic for infants, as a soothing bath for fevers, and in poultices for migraine headaches.(2) Indigenous peoples in Brazil use the leaf juice to wash infected wounds and place it in the eyes for eye problems,(3) and an make an infusion of the entire plant for an expectorant and emollient.(4)Indigenous tribes in Nicaragua use a hot water infusion and/or decoction of Vassourinha leaves or the whole plant for belly pain, menstrual disorders, as an aid in childbirth, to clean the blood, insect bites, fevers, heart problems, liver and stomach disorders, malaria, venereal disease, and for a general tonic.(5, 6)
Vassourinha is still employed in herbal medicine throughout the tropics. In Peru, a decoction of the entire plant is recommended for upper respiratory problems, menstrual disorders, and fever while the leaf juice is still employed for externally for wounds and hemorrhoids.(7, 8) In Brazilian herbal medicine, the plant is considered emollient, febrifuge, hypoglycemic, emmenagogue, hypotensive, pectoral and expectorant; used for upper respiratory disorders, bronchitis, coughs, menstrual disorders, diabetes, and hypertension just to name a few of its many uses.(9-12)
Some of Vassourinha's many uses in herbal medicine have been validated by research. In laboratory tests, it showed active properties against gram + bacteria (but not gram negative) and strong antifungal actions as well.(13, 14) Phytochemical screening of Vassourinha has shown that it is a source of novel flavonoids and terpene plant chemicals, some of which have not been seen in science before.(15,16) Many of Vassourinha's tested biological activities are attributed to these phytochemicals; the main ones being Scopadulcic Acids A & B, Scopadiol, Scopadulciol, Scopadulin, Scoparic Acids A, B, and C.(17 - 24) Vassourinha's hypoglycemic actions in two diabetic patients were reported in 1985.(25) In animal studies between 1993 and 1996, researchers showed that different extracts of Vassourinha demonstrated anti-inflammatory activity in rats, antispasmodic activity in guinea pigs and rats, analgesic actions in mice, and hypertensive properties in rats and dogs.(26, 27) In these animal studies they reported no toxicity in amounts up to 2 grams per kilogram of body weight. The antitumorous activity of scopadulcic acid B, one of Vassourinha's main active constituents, was demonstrated in a 1993 study.(28) This same phytochemical and another called Scopadulin demonstrated antiviral properties in two prior studies, including against Herpes Simplex I in vivo in hamsters.(29, 30) An ethanol extract of the whole plant of Vassourinha demonstrated an ability to inhibit receptor binding to both dopamine and serotonin receptors in another recent study.(31)
Scientists have been trying since the mid 1990's to synthesize several phytochemicals found in Vassourinha, including scopadulcic acid B, for their use in the pharmaceutical industry. Since before scientists became interested in Vassourinha, and probably long afterward, herbalists and natural health practitioners will continue to use the natural plant for a effective natural remedy for upper respiratory problems and viruses, menstrual problems, and as a natural hypotensive, analgesic and antispasmodic agent when needed.
Footnotes:
  1. Schultes, R.E., and Raffauf, 1990. The Healing Forest. Medicinal and Toxic Plants of the Northwest Amazonia, R.F. Dioscorides Press: Portland Oregon.

  2. Grenand, P., Moretti, C., Jacquemin, H., 1987. Pharmacopees taditionnels en Guyane: Créoles, Palikur, Wayãpi. Editorial l-ORSTROM, Coll. Mem No. 108. Paris, France

  3. Branch, L.C. and da Silva, I.M.F. 1983. "Folk Medicine of Alter do Chao, Para, Brazil." Acta Amazonica13(5/6):737-797.

  4. Hirschmann, G., et.al., 1990. A Survey of Medicinal Plants of Minas Gerais, Brazil. J Ethnopharmacol29 2: 159-172 (1990)

  5. Coee, F., et.al., 1996. Ethnobotany of the Garifuna of Eastern Nicaragua. Econ Bot 50 1: 71-107 (1996)

  6. Dennis, P. 1988. Herbal Medicine among the Miskito of Eastern Nicaragua. Econ Bot 42 1: 16-28 (1988)

  7. Ramirez, V., et.al. 1988. Vegetales Empleados En Medicina Tradicional Norperuana Banco Agrario Del Peru & Nacl Univ Trujillo, Trujillo, Peru, June, 1988 : 54pp- (1988)

  8. Kember Mejia and Reng, Elsa 1995. Plantas medicinales de uso popular en la Amazonia Peruana. AECI and IIAP: Lima, Peru.

  9. Cruz, G.L. 1995. Dicionario Das Plantas Uteis Do Brasil, 5th ed., Bertrand: Rio de Janeiro, Brazil

  10. Matos, FJ Abreu, 1994. Farmacias vivas, sistema de utilizaco de plantas medicinais projetado para pequenas comunidades. Edicoes UFC: Fortaleza, Brazil

  11. de Almeida, E.R., 1993. Plantas Medicinais Brasileiras, Conhecimentos Populares E Cientificos. Hemus Editora Ltda.: Sau Paulo, Brazil.

  12. Coimbra, Raul, 1994. Manual de Fitoterapia 2nd Ed., Editora Cejup: Belem, Brazil.

  13. Laurens, A., et.al., 1985 Antimicrobial Activity of Some Medicinal Species of Dakar Markets. Pharmazie 40 7: 482-485 (1985)

  14. Singh, J., et.al., 1994 Antifungal Activity of Mentha spicata. Int J Pharmacog 32 4: 314-319 (1994)

  15. Ramesh, P., et.al. 1979. Flavonoids of Scoparia dulcis and Stemodia viscosa Curr Sci 48 : 67- (1979)

  16. Mahato, S., et al., 1981. Triterpenoids of Scoparia dulcis. Phytochemistry 20 : 171-173 (1981)

  17. Hayashi, T., et.al. 1987 Scopadulcic Acid-a and -B, New Diterpenoids with a Novel Skeleton, from a Paraguayan Crude Drug "Typycha Kuratu" (Scoparia dulcis L.). Tetrahedron Lett 28 32: 3693-3696 (1987)

  18. Kawasaki, M., 1987 Structure of Scoparic Acid A, a New Labdane-type Diterpenoid from a Paraguayan Crude Drug "Typycha Kurata" (Scoparia dulcis L.).Chem Pharm Bull 35 9: 3963-3966 (1987)

  19. Hayashi, T., 1987 Structures of New Diterpenoids from Paraguayan Crude Drug "Typycha Kuratu" (Scoparia Dulcis L.).Tennen Yuki Kagobutsu Toronkai Koen Yoshishu 29 : 544-551 (1987)

  20. Hayashi, T., 1990 Antiviral Agents of Plant Origin. Iii. Scopadulin, a Novel Tetracyclic Diterpene from Scoparia dulcis L. Chem Pharm Bull 38 4: 945-947 (1990)

  21. Ahmed, M., 1990 Diterpenoids from Scoparia dulcis. Phytochemistry 29 9: 3035-3037 (1990)

  22. Hayashi, T., 1991 Scopadulciol, an Inhibitor of Gastric H+, K+-atpase from Scoparia dulcis, and its Structure-activity Relationships. J Nat Prod 54 3: 802-809 (1991)

  23. Hayashi, T., 1992 Scoparic Acid A, a Beta-glucuronidase Inhibitor from Scoparia dulcis. J Nat Prod55 12: 1748-1755 (1992)

  24. Hayashi, T., 1993. A New Chemotype of Scoparia dulcis. Phytochemistry 32 2: 349-352 (1993)

  25. Jain, H. C., 1985 Indian Plants with Oral Hypoglycaemic Activity. Abstr Internat Res Cong Nat Prod Coll Pharm, Univ N Carolina Chapel Hill NC July 7-12 1985 : Abstr-152 (1985)

  26. Freire, S., et.al., 1996. Sympathomimetic Effects of Scoparia dulcis L. and Catecholamines Isolated from Plant Extracts. J Pharm Pharmacol 48 6: 624-628 (1996)

  27. Freire, S., et.al., 1993. Analgesic and Antiinflammatory Properties of Scoparia dulcis L. Extracts and Glutinol in Rodents. Phytother Res 7 6: 408-414 (1993)

  28. Nishino H, 1993. Antitumor-promoting activity of scopadulcic acid B, isolated from the medicinal plant Scoparia dulcis L. Oncology 50(2), 100-103 (1993)

  29. Hayashi T, 1990. Antiviral agents of plant origin. III. Scopadulin, a novel tetracyclic diterpene from Scoparia dulcis L. Chem Pharm Bull (Tokyo) 38(4), 945-947 (1990)

  30. Hayashi K, 1988. In vitro and in vivo antiviral activity of scopadulcic acid B from Scoparia dulcis, Scrophulariaceae, against herpes simplex virus type 1. Antiviral Res 9(6), 345-354 (1988)

  31. Hasrat, J., et.,al., 1997 Medicinal Plants in Surianame: Screening of Plant Extracts for Receptor Binding Activity. Phytomedicine 4 1: 59-65 (1997)
REFERENCED QUOTES ON YERBA MATE
10 "Scoparia dulcis L. Scrophulariaceae. "Bati matsoti", "Escobilla", "Ñucñu-pichana", "Piqui pichana". Leaf infusion used for bronchitis, cough, diarrhea, fevers, kidney diseases, and hemorrhoids (RVM, VDF). Leaf infusion antidiarrheic and emetic (CAA). Antiseptic leaf decoction used for wounds; and fever. "Créoles" use the leaf decoction mixed with maternal milk as an antiemetic for infants. Dried leaves used by as a marihuana substitute. "Palikur" use the leaf decoction in antipyretic baths and in poultices for migraine headaches (GMJ). Ecuadorians take the tea for pain and swelling (SAR). "Tikuna" drink the tea, with or without "paico", three days during the menses as an abortifacient or contraceptive (SAR). Four to five plants tied together make the typical river-dweller's broom (RVM). Brazilians add the root to the bath when "cleaning their blood" (BDS). They apply strained leaf juice for eye ailments; and to infected wounds (erysipelas) (BDS)."
Clinical References
  1. Freire SM, 1996. Sympathomimetic effects of Scoparia dulcis L. and catecholamines isolated from plant extracts. J Pharm Pharmacol 48(6), 624-628 (1996)

  2. Nishino H, 1993. Antitumor-promoting activity of scopadulcic acid B, isolated from the medicinal plant Scoparia dulcis L. Oncology 50(2), 100-103 (1993)

  3. Hayashi T, 1992. Scoparic acid A, a beta-glucuronidase inhibitor from Scoparia dulcis. J Nat Prod 55(12), 1748-1755 (1992)

  4. Hayashi T, 1991. Scopadulciol, an inhibitor of gastric H+, K(+)-ATPase from Scoparia dulcis, and its structure-activity relationships. J Nat Prod 54(3), 802-809 (1991)

  5. Freire SM, 1991. Analgesic activity of a triterpene isolated from Scoparia dulcis L. (Vassourinha). Mem Inst Oswaldo Cruz 86, 149-151 (1991)

  6. Asano S, 1990. Reversible inhibitions of gastric H+,K(+)-ATPase by scopadulcic acid B and diacetyl scopadol. New biochemical tools of H+,K(+)-ATPase. J Biol Chem 265(36), 22167-22173 (1990)

  7. Hayashi T, 1990. Scopadulcic acid B, a new tetracyclic diterpenoid from Scoparia dulcis L. Its structure, H+, K(+)-adenosine triphosphatase inhibitory activity and pharmacokinetic
    behaviour in rats. Chem Pharm Bull (Tokyo) 38(10), 2740-2745 (1990)

  8. Hayashi T, 1990. Antiviral agents of plant origin. III. Scopadulin, a novel tetracyclic diterpene from Scoparia dulcis L. Chem Pharm Bull (Tokyo) 38(4), 945-947 (1990)

  9. Hayashi T, 1988. A cytotoxic flavone from Scoparia dulcis L. Chem Pharm Bull (Tokyo) 36(12), 4849-4851 (1988)

  10. Hayashi K, 1988. In vitro and in vivo antiviral activity of scopadulcic acid B from Scoparia dulcis, Scrophulariaceae, against herpes simplex virus type 1. Antiviral Res 9(6), 345-354 (1988)

  11. Kawasaki M, 1987. Structure of scoparic acid A, a new labdane-type diterpenoid from a Paraguayan crude drug "Typycha Kuratu" (Scoparia dulcis L.) Chem Pharm Bull (Tokyo) 35(9), 3963-3966 (1987
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